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Gary Birnbaum, MD
Feb 24, 20216 min read
To D or not to D? Now we know!
The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study...
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Gary Birnbaum, MD
Jan 30, 20215 min read
Oxygen for MS?
Bottom Line: Multiple sclerosis is a heterogeneous disease. It is, in my opinion, a syndrome like pneumonia, that is an illness with...
111 views0 comments
Gary Birnbaum, MD
Dec 29, 20206 min read
A novel but possible approach for preventing COVID-19
Paper #1: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, et al. Science 370,...
89 views0 comments
Gary Birnbaum, MD
Dec 10, 20206 min read
Wearing one's MS
Paper #1: Wearable technologies to measure clinical outcomes in multiple sclerosis: A scoping review Alexander, S., Peryer, G., Gray, E.,...
63 views0 comments
Gary Birnbaum, MD
Oct 29, 20205 min read
One DMT may not be enough
Paper #1: Silent Progression in Disease Activity–Free Relapsing Multiple Sclerosis University of California, San Francisco MS-EPIC Team,...
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Gary Birnbaum, MD
Aug 13, 20207 min read
A most important observation!
Bottom Line: Recent work in persons with MS suggests that the gut microbiome (the population of bacteria in the gut) is altered in MS,...
115 views0 comments
Gary Birnbaum, MD
Jul 3, 20209 min read
Yes? No? Maybe? Making treatment decisions during the coronavirus pandemic
A list of summarized articles is at the end of this posting. Bottom Line: There are at least four critical questions that persons with MS...
228 views0 comments
Gary Birnbaum, MD
Jun 4, 20205 min read
Is there a brain susceptibility to MS?
Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor DC, Barbeau AM, Allan KC, et al. Cell....
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Gary Birnbaum, MD
May 16, 20205 min read
Repairing an injured brain with gold
Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis....
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Gary Birnbaum, MD
Apr 16, 202010 min read
Is there a need for NEDA?
Paper #1: Using clinically stable disease (NEDA 2) as a proxy for disease impact and employment in MS paints an incomplete picture. Roman...
1,652 views0 comments
Gary Birnbaum, MD
Feb 23, 20206 min read
RIS: To treat or not to treat, that is the question
Treatment Considerations in the Radiologically Isolated Syndrome. Makhani N. Curr Treat Options Neurol. 2020;22:3....
154 views0 comments
Gary Birnbaum, MD
Jan 29, 202011 min read
A gut feeling for the brain
Paper #1: An overview of the current state of evidence for the role of specific diets in multiple sclerosis. Evans E, Levasseur V, Cross...
95 views0 comments
Gary Birnbaum, MD
Dec 19, 20195 min read
Avoiding Disease Rebound
Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: Analysis of predisposing factors. Sepulveda...
282 views0 comments
Gary Birnbaum, MD
Oct 31, 20196 min read
Can pregnancy help solve some of the mysteries of MS?
T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber...
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Gary Birnbaum, MD
Oct 5, 20195 min read
Looking backward to capture the future
Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis Kjetil Bjornevik, MD, PhD; Kassandra L. Munger,...
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Gary Birnbaum, MD
Sep 21, 20196 min read
Can one predict the course of MS?
Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS Sinah Engel,* Michaela...
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Gary Birnbaum, MD
Aug 11, 20194 min read
Can a "silent" virus infection trigger MS?
Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice Steinbach, K., Vincenti, I., Egervari, K....
64 views0 comments
Gary Birnbaum, MD
Jul 15, 20193 min read
Making MS personal
POST-MORTEM MULTIPLE SCLEROSIS LESION PATHOLOGY IS INFLUENCED BY SINGLE NUCLEOTIDE POLYMORPHISMS Nina L. Fransen, Jakob B.A. Crusius,...
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Gary Birnbaum, MD
Jul 1, 20194 min read
Do I really have MS?
Paper #1 - "Better explanations" in multiple sclerosis diagnostic workup: A 3-year longitudinal study. Calabrese M, Gasperini C,...
69 views0 comments
Gary Birnbaum, MD
Jun 14, 20194 min read
Identical but not!
DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis. Nicole Y. Souren, Lisa A. Gerdes, Pavlo...
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