Gary Birnbaum, MD
A novel but possible approach for preventing COVID-19
Paper #1: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, et al. Science 370,...
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Gary Birnbaum, MD
Dec 10, 20206 min read
Wearing one's MS
Paper #1: Wearable technologies to measure clinical outcomes in multiple sclerosis: A scoping review Alexander, S., Peryer, G., Gray, E.,...
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Gary Birnbaum, MD
Oct 29, 20205 min read
One DMT may not be enough
Paper #1: Silent Progression in Disease Activity–Free Relapsing Multiple Sclerosis University of California, San Francisco MS-EPIC Team,...
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Gary Birnbaum, MD
Aug 13, 20207 min read
A most important observation!
Bottom Line: Recent work in persons with MS suggests that the gut microbiome (the population of bacteria in the gut) is altered in MS,...
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Gary Birnbaum, MD
Jul 3, 20209 min read
Yes? No? Maybe? Making treatment decisions during the coronavirus pandemic
A list of summarized articles is at the end of this posting. Bottom Line: There are at least four critical questions that persons with MS...
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Gary Birnbaum, MD
Jun 4, 20205 min read
Is there a brain susceptibility to MS?
Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor DC, Barbeau AM, Allan KC, et al. Cell....
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Gary Birnbaum, MD
May 16, 20205 min read
Repairing an injured brain with gold
Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis....
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Gary Birnbaum, MD
Apr 16, 202010 min read
Is there a need for NEDA?
Paper #1: Using clinically stable disease (NEDA 2) as a proxy for disease impact and employment in MS paints an incomplete picture. Roman...
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Gary Birnbaum, MD
Feb 23, 20206 min read
RIS: To treat or not to treat, that is the question
Treatment Considerations in the Radiologically Isolated Syndrome. Makhani N. Curr Treat Options Neurol. 2020;22:3....
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Gary Birnbaum, MD
Jan 29, 202011 min read
A gut feeling for the brain
Paper #1: An overview of the current state of evidence for the role of specific diets in multiple sclerosis. Evans E, Levasseur V, Cross...
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Gary Birnbaum, MD
Dec 19, 20195 min read
Avoiding Disease Rebound
Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: Analysis of predisposing factors. Sepulveda...
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Gary Birnbaum, MD
Oct 31, 20196 min read
Can pregnancy help solve some of the mysteries of MS?
T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber...
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Gary Birnbaum, MD
Oct 5, 20195 min read
Looking backward to capture the future
Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis Kjetil Bjornevik, MD, PhD; Kassandra L. Munger,...
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Gary Birnbaum, MD
Sep 21, 20196 min read
Can one predict the course of MS?
Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS Sinah Engel,* Michaela...
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Gary Birnbaum, MD
Aug 11, 20194 min read
Can a "silent" virus infection trigger MS?
Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice Steinbach, K., Vincenti, I., Egervari, K....
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Gary Birnbaum, MD
Jul 15, 20193 min read
Making MS personal
POST-MORTEM MULTIPLE SCLEROSIS LESION PATHOLOGY IS INFLUENCED BY SINGLE NUCLEOTIDE POLYMORPHISMS Nina L. Fransen, Jakob B.A. Crusius,...
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Gary Birnbaum, MD
Jul 1, 20194 min read
Do I really have MS?
Paper #1 - "Better explanations" in multiple sclerosis diagnostic workup: A 3-year longitudinal study. Calabrese M, Gasperini C,...
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Gary Birnbaum, MD
Jun 14, 20194 min read
Identical but not!
DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis. Nicole Y. Souren, Lisa A. Gerdes, Pavlo...
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Gary Birnbaum, MD
May 16, 20193 min read
Inside-Out or Outside-In?
Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Jianqin Niu, Hui-Hsin Tsai,...
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Gary Birnbaum, MD
Apr 29, 20194 min read
D for all MS?
The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR Ming Lu, Bennet J....
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